Preparation and Evaluation of the Antibacterial Activity of Oxazolidine-5-One Derivatives

As part of the study, novel oxazolidinone-5 compounds were created by reacting hydrazones with chlorosulfuric acid while THF was present as a solvent. Melting point, yield, and color measurements were utilized to monitor and characterize the reaction, which was prepared using the sublimation method. Thin Layer Chromatography (TLC), The completeness of the process was shown using Fourier Transform Infrared Spectroscopy (FT-IR) and proton and carbon nuclear magnetic resonance (1H and 13C-NMR). The impact of the produced chemicals on the development of two antibiotic-resistant bacterial strains Gram-positive (Staph. epidermidis) and Gram-negative (K. pneumoniae) was used to assess their biological activity. The control sample was the antibiotic ampicillin.