The Effect of Sleep Pattern on Reproductive Hormones in Females
Downloads
Background: Sleep is the body's rest cycle. Sleep has stimulated by a complex set of mainly active hormones, which respond to signals from the body itself and it’s environment.
Methodology: This study was conducted on 50 women from the population with age of (18_25) years old,25 women who suffer from a sleep disorder were considered as a case group and other 25 women with normal and regulated sleep were considered as control group. Samples were collected during the menstrual cycle, by using a gel tube
to measure the levels of the following hormones (FSH, LH, Progesterone, E2).
Results: The study showed a statistical significant increase in the level of progesterone) p = 0.001) and a decrease in the level of FSH (p=0.02), while the other parameters including study show that there isn’t significant difference between two groups.
Conclusion: Sleep disturbance may have a significant impact on a woman's health.
1. Durmer JS, Dinges DF. Neurocognitive consequences of sleep deprivation. Semin Neurol. 2005; 25:117–29.
2. Claudio N Soares, Brian J Murray Psychiatric Clinics 29 (4), 1095-1113, 2006
3. Messinis IE, Messini CI, Dafopoulos K. Novel aspects of the endocrinology of the menstrual cycle. Reproduct BioMed. (2014) 28:714–22. doi: 10.1016/j.rbmo.2014.02.003
4. Huhtaniemi I. A sho-stimulated spermatogenesis. Hormones. (2015) 14:468–78. doi: 10.14310/horm.2002.1632
5. evolutionary history of FSH3. Stamatiades GA, Kaiser UB. Gonadotropin regulation by pulsatile GnRH: signaling and gene expression. Mol Cell Endocrinol. (2018) 463:131– 41. doi: 10.1016/j.mce.2017.10.015
6. Nedresky D, Singh G. Physiology, Luteinizing Hormone. In: StatPearls. StatPearls Publishing, Treasure Island (FL); 2023. PMID: 30969514.
7. Cable JK, Grider MH. Physiology, Progesterone. In: StatPearls. StatPearls Publishing, Treasure Island (FL); 2023. PMID: 32644386.
8. Ryan KJ (August 1982). "Biochemistry of aromatase: significance to female reproductive physiology". Cancer Research. 42 (8 Suppl): 3342s–3344s. PMID 7083198.
9. Molecular Life Sciences. 40 (9): 942–944. doi:10.1007/BF01946450. S2CID 31950471.
10. Ozon R (1972). "Estrogens in Fishes, Amphibians, Reptiles, and Birds". In Idler DR (ed.). Steroids In Nonmammalian Vertebrates. Oxford: Elsevier Science. pp. 390–414. ISBN 978-0323140980.
11. Saldanha, Colin J., Luke Remage-Healey, and Barney A. Schlinger. "Synaptocrine signaling: steroid synthesis and action at the synapse." Endocrine reviews 32.4 (2011): 532–549.
12. Chidi-Ogbolu N, Baar K. Effect of estrogen on musculoskeletal performance and injury risk (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341375/). Front Physiol. 2019;9:1834. Published 2019 Jan 15. Accessed 2/7/2022.
13. Erol A, Ho AM, Winham SJ, Karpyak VM. Sex hormones in alcohol consumption: a systematic review of evidence. (https://pubmed.ncbi.nlm.nih.gov/29280252/) Addict Biol. 2019;24(2):157-169. Accessed 2/7/2022.
14. Fuentes N, Silveyra P. Estrogen receptor signaling mechanisms (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533072/). Adv Protein Chem Struct Biol. 2019;116:135-170. Accessed 2/7/2022.
15. Schulster M, Bernie AM, Ramasamy Chen C, Gong X, Yang X, et al. The roles of estrogen and estrogen receptors in gastrointestinal disease. (https://pubmed.ncbi.nlm.nih.gov/31788039/) Oncol Lett. 2019;18(6):5673-5680. Accessed 2/7/2022.
16. R. The role of estradiol in male reproductive function (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854098/) . Asian J Androl. 2016;18(3):435-440. Accessed 2/7/2022.
17. IGabriela Beroukhim* , Ecem Esencan and David B. Seifer. Impact of sleep patterns upon female neuroendocrinology and reproductive outcomes: a comprehensive. a review. Reproductive Biology and Endocrinology volume (2022), 20 (16).
18. Jamie Coborn, Anouk de Wit, Sybil Crawford, Margo Nathan, Shadab Rahman, Lauren Finkelstein, Aleta Wiley, Hadine Joffe, Disruption of Sleep Continuity During the Perimenopause: Associations with Female Reproductive Hormone Profiles, The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 10, October 2022, Pages e4144–e4153, https://doi.org/10.1210/clinem/dgac447.
19. Robert L. Rosenfield, Brian Bordini, Christine Yu, Comparison of Detection of Normal Puberty in Girls by a Hormonal Sleep Test and a Gonadotropin-Releasing Hormone Agonist Test, The Journal of Clinical Endocrinology & Metabolism, Volume 98, Issue 4, 1 April 2013, Pages 1591–1601, https://doi.org/10.1210/jc.2012-4136
20. Cable JK, Grider MH. Physiology, Progesterone. [Updated 2022 May 8; cited 2022 Jun 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK558960/
21. Mayo Clinic: Mayo Medical Laboratories [Internet]. Mayo Foundation for Medical Education and Research; c1995–2012. Test ID: PGSN: Progesterone Serum: Overview; [cited 2022 Jun 21]; [about 2 screens]. Available from: https://www.mayomedicallaboratories.com/test-catalog/Overview/8141
22. Merck Manual Consumer Version [Internet]. Kenilworth (NJ): Merck & Co. Inc.; c2022. Overview of the Female Reproductive System; [reviewed 2022 Apr; cited 2022 Jun 21]; [about 2 screens]. Available from: https://www.merckmanuals.com/home/women-s-health.
23. Testing.com [Internet]. Seattle (WA).: OneCare Media; c2022. Progesterone; [modified 2021 Nov 9; cited 2022 June 21]; [about 12 screens]. Available from: https://www.testing.com/tests/progesterone
24. UF Health: University of Florida Health [Internet]. University of Florida; c2022. Serum Progesterone: Overview; [updated 2019 Mar 28; cited 2022 Jun 21]; [about 2 screens]. Available from: https://ufhealth.org/serum-progesterone
25. University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; c2022. Health Encyclopedia: Progesterone; [cited 2022 Jun 21]; [about 4 screens]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&
26. UW Health [Internet]. Madison (WI): University of Wisconsin Hospitals and Clinics Authority; c2022. Health Information: Progesterone: Results; [current 2022 Feb 23; cited 2022 Jun 213]; [about 6 screens]. Available from: https://patient.uwhealth.org/healthwise/article/en-us/hw42146
27. WomensHealth.gov [Internet]. Washington DC: Office on Women's Health, U.S. Department of Health and Human Services; Menstrual Cycle: Your Menstrual Cycle; [updated 2021 Feb 22; cited 2022 Jun 21]; [about 4 screens]. Available from: https://www.womenshealth.gov/menstrual-cycle/your-menstrual-cycle
28. Cleveland Clinic: Health Library: Diagnostics & Testing [Internet]. Cleveland (OH): Cleveland Clinic; c2023.Follicle-Stimulating Hormone (FSH); [reviewed 2023 Jan 23; cited 2023 May 8]; [about 19 screens]. Available from: https://my.clevelandclinic.org/health/articles/24638-follicle-stimulating-hormone-fsh 29) Cleveland Clinic: Health Library: Diagnostics & Testing [Internet]. Cleveland (OH): Cleveland Clinic; c2023. Premature Menopause; [reviewed 2022 Sept 6; cited 2023 May 8]; [about 14 screens]. Available from: https://my.clevelandclinic.org/health/diseases/21138-premature-and-earlymenopause#diagnosis-and-tests
30. Jabbour S. Follicle-Stimulating Hormone Abnormalities [updated 2020 Apr 1; cited 2023 May 9]. In: Medscape: Drugs & Diseases: Endocrinology [Internet]. Atlanta (GA): WebMD LLC; c1994-2023. Available from: https://emedicine.medscape.com/article/118810-overview
31. Mayo Clinic [Internet]. Mayo Foundation for Medical Education and Research; c19982023. Menopause; [cited 2023 May 8]; [about 10 screens]. Available from: https://www.mayoclinic.org/diseases-conditions/menopause/diagnosistreatment/drc-20353401
32. Mayo Clinic: Mayo Medical Laboratories [Internet]. Mayo Foundation for Medical Education and Research; c1995-2022. Test ID: FSH: Follicle-Stimulating Hormone (FSH), Serum; [cited 2023 May 8]; [about 3 screens]. Available from: https://www.mayocliniclabs.com/test-catalog/Overview/602753#Clinical .
33. Orlowski M, Sarao MS. Physiology, Follicle Stimulating Hormone. [Updated 2022 May 8; cited 2023 May 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearlsPublishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK535442/#_article-21867_s9_
34. Office on Women's Health [Internet]. Washington D.C.U.S. Department of Health and Human Services; Menopause Basics; [updated 2023 Jan 6; cited 2023 May 4]; [about 5 screens]. Available from: https://www.womenshealth.gov/menopause/menopause-
35. esting.com [Internet]. Seattle (WA): OneCare Media; c2023. Follicle-stimulating Hormone (FSH) Test; [modified 2023 Jan 5; cited 2023 May 8]; [about 13 screens]. Available from: https://www.testing.com/tests/follicle-stimulating-hormone-fsh/ 36) Testing.com [Internet]. Seattle (WA): OneCare Media; c2023. Menopause Testing; [modified 2021 Nov 9; cited 2023 May 8]; [about 7 screens]. Available from: https://www.testing.com/menopause-testing/
37. UF Health: University of Florida Health [Internet]. Gainesville (FL): University of Florida Health; c2023. Follicle-stimulating hormone (FSH) blood test: Overview; [reviewed 2019 Jun 30; cited 2023 May 4]; [about 3 screens]. Available from: https://ufhealth.org/follicle-stimulating-hormone-fsh-blood-test
38. UW Health [Internet]. Madison (WI): University of Wisconsin Hospitals and Clinics Authority; c2023. Health Information: Follicle-Stimulating Hormone; [updated 2022 Sep 8; cited 2023 May 4]; [about 2 screens]. Available from: https://patient.uwhealth.org/healthwise/article/en-us/hw7924
39. Cleveland Clinic: Health Library [Internet]. Cleveland (OH): Cleveland Clinic; c2023. Body Systems & Organs: Luteinizing Hormone; [reviewed 2022 Jan 8; cited 2023 May 22]; [about 10 screens]. Available from: https://my.clevelandclinic.org/health/body/22255-luteinizing-hormone
40. Cleveland Clinic: Health Library [Internet]. Cleveland (OH): Cleveland Clinic; c2023. Diseases & Conditions: Premature and Early Menopause; [reviewed 2022 Sep 6; cited 2023 May 22]; [about 11 screens]. Available from: https://my.clevelandclinic.org/health/diseases/21138-premature-and-earlymenopause#diagnosis-and-tests
41. Eunice Kennedy Shriver National Institute of Child Health and Human Development [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; How Do Healthcare Providers Diagnose Menopause?; [reviewed 2021 Nov 16; cited 2023 May 22]; [about 2 screens]. Available from: https://www.nichd.nih.gov/health/topics/menopause/conditioninfo/diagnosed
42. Testing.com [Internet]. Seattle (WA): OneCare Media; c2023. Pregnancy and Fertility Testing; [modified 2022 Oct 4; cited 2023 May 22]; [about 11 screens]. Available from: https://www.testing.com/fertility-testing/
43. Testing.com [Internet]. Seattle (WA): OneCare Media; c2023. Luteinizing Hormone (LH) Test; [modified 2022 Dec 21; cited 2023 May 22]; [about 13 screens]. Available from: https://www.testing.com/tests/luteinizing-hormone-lh/
44. Testing.com [Internet]. Seattle (WA): OneCare Media; c2023. Menopause; [modified 2021 Nov 9; cited 2023 May 22]; [about 7 screens]. Available from: https://www.testing.com/menopause-testing/
