Development of Cosmetic Treatments Based on Chemistry, Laser, and Biotechnology: An Integrated Study on the Effects of Active Compounds on Skin Cell Regeneration
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Cosmetic products for skin regeneration typically target keratinocytes and fibroblasts, but conventional formulations allow limited penetration and bioavailability. In integrated protocols, Chemistry, Laser, and Biotechnology approaches synergistically enhance skin penetration and action, potentially improving regeneration efficacy. Chemistry contributions encompass formulation and delivery technology to optimize active compound design and incorporation. Laser-based strategies exploit laser principles to augment the influence of active compounds. Biotechnological innovations, encompassing cell-based, biomaterial, and gene-modified approaches, complement active-compound therapies. An integrated protocol uniting the three modalities is envisioned, with Chemistry, Laser, and Biotechnology interactions forming the foundation for future personalizable regimens.
1. M. M Loesch, A. K. Somani, M. M Kingsley, J. B Travers et al., "Skin resurfacing procedures: new and emerging options," 2014. ncbi.nlm.nih.gov
2. M. J. Flagler, M. Tamura, T. Laughlin, S. Hartman et al., "Combinations of peptides synergistically activate the regenerative capacity of skin cells in vitro," 2021. ncbi.nlm.nih.gov
3. J. Zheng, B. Yang, S. Liu, Z. Xu et al., "Applications of Exosomal miRNAs from Mesenchymal Stem Cells as Skin Boosters," 2024. ncbi.nlm.nih.gov
4. A. Möbius, "Wirkung fraktional ablativer Lasersysteme in der Therapie der gealterten und chronisch lichtgeschädigten Haut," 2013. [PDF]
5. E. Frank Bragato, J. André Pires, M. Momolli, M. Bertoni Guerra et al., "Comparison of the effects of 2 frequencies of application of photobiomodulation on facial rejuvenation: Controlled, randomized, and double-blind clinical trial," 2023. ncbi.nlm.nih.gov
6. M. Teresa Truchuelo and M. Vitale, "A cosmetic treatment based on the secretion of Cryptomphalus aspersa 40% improves the clinical results after the use of nonablative fractional laser in skin aging," 2019. ncbi.nlm.nih.gov
7. X. He, F. Wan, W. Su, and W. Xie, "Research Progress on Skin Aging and Active Ingredients," 2023. ncbi.nlm.nih.gov
8. X. He, X. Gao, Y. Guo, and W. Xie, "Research Progress on Bioactive Factors against Skin Aging," 2024. ncbi.nlm.nih.gov
9. V. Louise Van Kets, "An investigation into the cellular mechanisms underlying photodynamic rejuvenation in human skin," 2012. [PDF]
10. F. P. Morais, R. M. S. Simões, and J. M. R. Curto, "Biopolymeric Delivery Systems for Cosmetic Applications Using Chlorella vulgaris Algae and Tea Tree Essential Oil," 2020. ncbi.nlm.nih.gov
11. K. Žužul, "The use of lasers in dermatology," 2014. [PDF]
12. J. Borges, M. Manela-Azulay, and T. Cuzzi, "Photoaging and the clinical utility of fractional laser," 2016. ncbi.nlm.nih.gov
13. M. Lotfy Elsaie and H. Woolery Lloyd, "LATEST LASER AND LIGHT-BASED ADVANCES FOR ETHNIC SKIN REJUVENATION," 2008. ncbi.nlm.nih.gov
14. C. Mignon, "Photo-biomodulation of human skin fibroblast sub-populations: a systematic approach for the optimization of optical treatment parameters," 2017. [PDF]
15. Q. Hua Phua, H. Alexander Han, and B. S. Soh, "Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration," 2021. ncbi.nlm.nih.gov
16. V. W. Wong, B. Levi, J. Rajadas, M. T. Longaker et al., "Stem Cell Niches for Skin Regeneration," 2012. ncbi.nlm.nih.gov
17. T. AH Järvinen, U. May, and S. Prince, "Systemically Administered, Target Organ-Specific Therapies for Regenerative Medicine," 2015. [PDF]
18. A. A. Chaudhari, K. Vig, D. Radé Baganizi, R. Sahu et al., "Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review," 2016. ncbi.nlm.nih.gov
19. J. Naval, V. Alonso, and M. Angel Herranz, "Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments," 2014. ncbi.nlm.nih.gov
20. H. Mertsching, M. Weimer, S. Kersen, and H. Brunner, "Human skin equivalent as an alternative to animal testing," 2008. ncbi.nlm.nih.gov
21. M. J. Randall, A. Jüngel, M. Rimann, M. Rimann et al., "Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models," 2018. [PDF]
22. M. E. Darvin, "Optical Methods for Non-Invasive Determination of Skin Penetration: Current Trends, Advances, Possibilities, Prospects, and Translation into In Vivo Human Studies," 2023. ncbi.nlm.nih.gov
23. N. Ilić, S. Savić, E. Siegel, K. Atkinson et al., "Examination of the Regulatory Frameworks Applicable to Biologic Drugs (Including Stem Cells and Their Progeny) in Europe, the US, and Australia: Part I-A Method of Manual Documentary Analysis," 2012. [PDF]
24. K. Alhallak, D. Omran, S. Tomi, and A. Abdulhafid, "Skin, light and their interactions, an in-depth review for modern light-based skin therapies," J. Clin. Derm. Ther, 2021. researchgate.net
25. M. C. Meinke, L. Busch, and S. B. Lohan, "Wavelength, dose, skin type and skin model related radical formation in skin," Biophysical reviews, 2021. springer.com

