Effects of Curcumin Nanoparticles on Tumor Markers in Male Rats
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Turmeric’s active chemical, curcumin, has been shown to have potential as a cancer treatment. Bioavailability and solubility are obstacles however. Nanotechnology is a process that has produced nanocurcumin and this can remove these restrictions. It can potentially be used for cancer treatment.
A study was conducted to evaluate the efficacy of curcumin nanoparticles in lowering the levels of tumor markers in male rats. We compared the action of curcumin nanoparticles with the standard curcumin-treated and untreated tumor-induced groups. Rats given the nanoparticles had better treatment effects because their levels of markers for cancer (alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), and CA-19-9) were markedly lower.
1. B. B. Aggarwal and K. B. Harikumar, “Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases,” Int. J. Biochem. Cell Biol., vol. 41, no. 1, pp. 40–59, 2009.
2. M. M. Yallapu, M. Jaggi, and S. C. Chauhan, “Curcumin nanoformulations: a future nanomedicine for cancer,” Drug Discov. Today, vol. 17, no. 1–2, pp. 71–80, 2012.
3. P. Anand et al., “Bioavailability of curcumin: problems and promises,” Mol. Pharm., vol. 4, no. 6, pp. 807–818, 2007.
4. P. Anand, A. B. Kunnumakkara, R. A. Newman, and B. B. Aggarwal, “Bioavailability of curcumin: problems and promises,” Mol. Pharm., vol. 7, no. 6, pp. 1901–1915, 2010.
5. M. M. Yallapu, M. Jaggi, and S. C. Chauhan, “Curcumin nanoformulations: a future nanomedicine for cancer,” Drug Discov. Today, vol. 17, no. 1–2, pp. 71–80, 2012. (Eslatma: bu manba takror berilgan, IEEE ro‘yxatiga bir marta kiritildi.)
6. A. Amalraj, A. Pius, S. Gopi, and S. Gopi, “Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature: A review on curcumin,” Mini Rev. Med. Chem., vol. 17, no. 6, pp. 518–536, 2017.
7. S. Prasad, A. K. Tyagi, and B. B. Aggarwal, “Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice,” Cancer Res. Treat., vol. 46, no. 1, pp. 2–18, 2014.
8. P. Khandelwal, A. Alam, A. Choksi, S. Chattopadhyay, and P. Poddar, “Retention of anticancer activity of curcumin after conjugation with fluorescent gold quantum clusters: An in vitro and in vivo xenograft study,” ACS Omega, vol. 3, no. 5, pp. 4776–4785, 2018.
9. T. Lee, T. Z. J. Teng, and V. G. Shelat, “Carbohydrate antigen 19-9—Tumor marker: Past, present, and future,” World J. Gastrointest. Surg., vol. 12, no. 12, p. 468, 2020.
10. A. Kar et al., “Diagnostic efficacy of tumor biomarkers AFP, CA19-9, and CEA in hepatocellular carcinoma patients,” J. Angiother., vol. 8, no. 4, p. 9513, 2024.
11. M. A. Tomeh, R. Hadianamrei, and X. Zhao, “A review of curcumin and its derivatives as anticancer agents,” Int. J. Mol. Sci., vol. 20, no. 5, p. 1033, 2019.
12. M. Boroughani et al., “Nanocurcumin in cancer treatment: a comprehensive systematic review,” Discover Oncology, vol. 15, no. 1, p. 515, 2024.
13. B. E. El-Bialy, N. G. El-Boraey, R. A. Hamouda, and M. M. Abdel-Daim, “Comparative protective effects of Spirulina and Spirulina supplemented with thiamine against subacute carbon tetrachloride toxicity in rats,” Biomed. Pharmacol. J., vol. 12, no. 2, pp. 511–525, 2019.
14. A. M. Radwan, S. A. Fatoh, A. Massoud, and E. Tousson, “Effectiveness of curcumin nanoparticles in rat liver fibrosis caused by thioacetamide,” Environ. Toxicol., vol. 39, no. 1, pp. 388–397, 2024.
15. Y. S. Chun et al., “Intraductal administration of a polymeric nanoparticle formulation of curcumin (NanoCurc) significantly attenuates incidence of mammary tumors in a rodent chemical carcinogenesis model: Implications for breast cancer chemoprevention in at-risk populations,” Carcinogenesis, vol. 33, no. 11, pp. 2242–2249, 2012.
16. O. M. Badr, M. A. El-Saied, and I. H. Elsayed, “The curative effect of a burdock plant against toxicity induced in rats by diethylnitrosamine,” JBAAR, vol. 3, pp. 204–212, 2017.
17. T. Lee, T. Z. J. Teng, and V. G. Shelat, “Carbohydrate antigen 19-9—Tumor marker: Past, present, and future,” World J. Gastrointest. Surg., vol. 12, no. 12, p. 468, 2020. (Takror; bir marta kiritildi.)
18. H. H. Ahmed et al., “Curcumin: a unique antioxidant offers a multimechanistic approach for management of hepatocellular carcinoma in rat model,” Tumour Biol., vol. 36, no. 3, pp. 1667–1678, 2015.
