Hepatobiliary System Involvement in Neonatal Sepsis: A Clinical and Morphological Study
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Neonatal sepsis remains a leading cause of mortality in the neonatal period and is frequently accompanied by multiple organ dysfunction. The hepatobiliary system plays a crucial role in metabolic regulation, immune response, and detoxification; therefore, its involvement reflects the severity and systemic nature of septic injury. However, clinical and morphological characteristics of hepatobiliary damage in neonatal sepsis have not been sufficiently systematized.
1. Afanasyev Yu.I., Yurina N.A. Histology, Cytology and Embryology. Moscow: GEOTAR-Media; 2019.
2. Zayratynats O.V., Kaktursky L.V. Pathomorphology of sepsis and septic shock. Archive of Pathology. 2016;78(4):3–9.
3. Nepomnyashchikh L.M. Morphological basis of multiple organ failure in sepsis. Bulletin of Experimental Biology and Medicine. 2014;158(6):701–706.
4. Strukov A.I., Serov V.V. Pathological Anatomy. 6th ed. Moscow: Litterra; 2015.
5. Vlasyuk V.V. Forensic medical assessment of morphological manifestations of sepsis in newborns. Forensic Medical Expertise. 2018;61(5):12–17.
6. Tadzhiev M.T., et al. Neonatal sepsis: clinical and morphological aspects of fatal outcomes. Medical Journal of Uzbekistan. 2021;4:45–50.
7. WHO. Guidelines on Neonatal Sepsis. World Health Organization; 2020.
8. Polin R.A. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012;129(5):1006–1015.
9. Shane A.L., Sánchez P.J., Stoll B.J. Neonatal sepsis. The Lancet. 2017;390(10104):1770–1780.
10. Cohen J. The immunopathogenesis of sepsis. Nature. 2002;420(6917):885–891.
11. Feldman A.G., Sokol R.J. Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics. Nature Reviews Gastroenterology & Hepatology. 2019;16:346–360.
12. Polin R.A. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012;129(5):1006–1015.
13. Cohen J. The immunopathogenesis of sepsis. Nature. 2002;420(6917):885–891.
14. Feldman A.G., Sokol R.J. Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics. Nature Reviews Gastroenterology & Hepatology. 2019;16:346–360.
