Сomparative Analysis of Postoperative Pain Syndrome in Cardioesophageal Cancer

Cardioesophageal cancer postoperative pain syndrome multimodal analgesia thoracophrenicolaparotomy thoracotomy Numeric Rating Scale oncology surgery analgesia effectiveness

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February 28, 2026

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Postoperative pain syndrome
(POPS) remains a significant clinical challenge in
patients undergoing surgery for cardioesophageal
cancer (CEC). Despite the implementation of
multimodal analgesia protocols, adequate pain
control is not consistently achieved. This study
aimed to comparatively assess postoperative pain
intensity depending on the type of surgical access
and tumor characteristics in patients with CEC.
Eighty-five patients who underwent open surgical
treatment were evaluated using the Numeric Rating
Scale (NRS). Pain intensity was analyzed in
relation to surgical approach, tumor phenotype,
disease stage, and demographic factors. The
highest pain intensity was observed in patients who
underwent
thoracophrenicolaparotomy.
Multimodal analgesia improved pain control;
however, pain levels exceeded the adequate
analgesia threshold (>4 points) in a substantial
proportion of patients. The findings indicate that
postoperative pain intensity is primarily associated
with the extent of surgical trauma rather than
gender or age factors, highlighting the need for
optimization of regional analgesia techniques in
oncologic surgery.