Effect of Therapeutic Properties of Curcuma Longa Rhizomes Extract on Some Selected Haematological Indices of Male Albino Wistar Rats Induced with Diabetes Mellitus
Downloads
Curcuma longa (Turmeric) is a nutraceutical plant commonly used as dietary spice in many cuisines, as analgesic agent to relief pain and traditionally in the treatment of various ailments. This study investigated the therapeutic effect of Curcuma longa rhizomes extract on some selected hematological indices of male albino Wistar rats induced with diabetes mellitus. Thirty (30) healthy and sexually matured male rats weighing between 180-220g were randomly distributed into six groups of five rats in each group, viz: group one served as Diabetic induced (180mg/kg alloxan prepared) + 200mg/kg (rhizomes extract of curcuma longa), group two as Diabetic induced (180mg/kg alloxan prepared) + 500mg/kg (rhizomes extract of curcuma longa), group three as Diabetic induced (180mg/kg alloxan prepared) + 700mg/kg (rhizomes extract of curcuma longa), group four as Diabetic induced + 500mg/kg of metformin, group five as Diabetic induced (negative untreated) and group six as Normal Control. At the end of the experiment, Neutrophil (Neu), Red Cell Distribution Width (RDW), Thickness Ratio of the Red Blood Cell (THR) and Mean Platelet Volume (MPV) were evaluated. Results indicated that significant (P<0.005) increase in the five hematological indices levels across the induced diabetic groups as compare to normal control (uninduced) group. However, the treated diabetic groups such as Diabetic induced + 200mg/kg (rhizomes extract of curcuma longa), Diabetic induced + 500mg/kg (rhizomes extract of curcuma longa), and Diabetic induced + 700mg/kg (rhizomes extract of curcuma longa) respectively indicated significant (P<0.005) decrease in the level of the hematological indices use in this study compare to diabetic induced untreated group. Also, the induced diabetic group treated with standard anti-diabetic drug (metformin) shewed significant (P<0.005) decrease in the levels NEU, RDW, THR and MPV as compare to untreated diabatic group. Furthermore, both rhizomes extract of curcuma longa and metformin reduces the elevated hematological parameters level in this study to a comparable level with normal control (uninduced) group. It can be concluded that the administration of graded doses (200mg/kg, 500mg/kg and 700mg/kg) of rhizomes extract of curcuma longa to diabetes induced group in the present study is effective in the management of hematological disorder that may arise from diabetes mellitus complications.
[1] C. A. Araujo and L. L. Leon, “Biological activities of Curcuma longa L.,” Memórias do Instituto Oswaldo Cruz, vol. 96, no. 5, p. 723, 2001.
[2] M. E. Braga, P. F. Leal, J. E. Carvalho, and M. A. Meireles, “Comparison of yield, composition and antioxidant activity of turmeric (Curcuma longa L.) extracts obtained using various techniques,” Journal of Agricultural and Food Chemistry, vol. 51, no. 22, pp. 6604–6611, 2003.
[3] E. A. Okon, E. U. Umoh, P. M. Bobson, I. G. Etim, and I. U. Sunday, “Comparative evaluation of aqueous leaf extracts and latex of Eleaphorbia drupifera,” American Journal of Bioscience and Clinical Integrity, vol. 1, no. 11, pp. 43–52, 2024.
[4] B. Kisacik, A. Tufan, U. Kalyoncu, O. Karadag, A. Akdogan, M. A. Ozturk, and S. Kiraz, “Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis,” Joint Bone Spine, vol. 75, no. 3, pp. 291–294, 2008.
[5] T. A. Kodiatte, U. K. Manikyam, S. B. Rao, T. M. Jagadish, M. Reddy, H. K. Lingaiah, and V. Lakshmaiah, “Mean platelet volume in type 2 diabetes mellitus,” Journal of Laboratory Physicians, vol. 4, no. 1, pp. 5–9, 2012.
[6] Y. U. Budak, K. Huysal, and M. Polat, “The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: A systematic review,” Clinica Chimica Acta, vol. 519, pp. 64–70, 2021.
[7] O. Akinloye, G. Oboh, O. A. Olagoke, and A. Adebayo, “Effect of streptozotocin-induced diabetes mellitus on haematological parameters in male albino Wistar rats,” Journal of Medical Sciences, vol. 14, no. 2, pp. 107–113, 2014.
[8] D. Ayoola, O. D. Adeyemi, O. O. Ogunlade, and O. F. Bamidele, “Diabetes mellitus and blood parameters in albino rats: A biochemical insight,” African Journal of Biomedicine, vol. 9, no. 1, pp. 56–62, 2016.
[9] I. J. Edem, N. E. Essien, A. A. Ekong, and M. B. Benjamin, “Evaluation of the ameliorative impacts of ethanol rhizome extract of Curcuma longa on hematological parameters of diabetes-induced male albino Wistar rats,” World Journal of Advanced Research and Reviews, vol. 28, no. 2, pp. 581–586, 2025.
[10] K. D. Pagana, T. D. Pagana, and T. N. Pagana, Mosby’s Diagnostic and Laboratory Test Reference, 17th ed., pp. 596–598, 2024.
[11] I. Ezeigbo, U. O. Okeke, P. A. Nwafor, and E. A. Alagwu, “Comparative study of haematological profile of diabetes and non-diabetic albino rats,” International Journal of Diabetes Research, vol. 9, no. 2, pp. 15–20, 2021.
[12] S. S. Nabavi, S. M. Nabavi, M. Sureda, A. Caprioli, M. Iannarelli, A. M. S. Nabavi, and S. M. A. Shirooie, “Curcumin: A natural product for diabetes and its complications,” Current Medicinal Chemistry, vol. 22, no. 23, pp. 2839–2855, 2015, doi: 10.2174/0929867322666150619142519.
[13] A. G. Elshazly, A. A. El-Kenawi, and M. M. El-Shazly, “Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications,” Evidence-Based Complementary and Alternative Medicine, 2012, doi: 10.1155/2012/486489.
[14] A. Menon and A. Sudheer, “Antioxidant and anti-inflammatory properties of curcumin,” Advances in Experimental Medicine and Biology, vol. 595, pp. 105–125, 2007, doi: 10.1007/978-0-387-46401-5_3.
[15] S. Sahebkar, “Curcumin: A pleiotropic phytonutrient in diabetic complications,” Molecular Nutrition & Food Research, vol. 58, no. 2, pp. 219–228, 2014, doi: 10.1002/mnfr.201300724.
