The Role of Analytical Chemistry in Modern Drug Development
Downloads
Analytical chemistry-the broad field of chemical research dedicated to the measurement and identification of substances deliberated or unwanted at a certain place and a certain time, underlies a great extent of all developments in chemistry. But unfortunately, analytical work as a somehow poor sister is not noticed by the public as much as important discoveries and new products get all the attention. Although it is not a new phenomenon, the verdict of analytical chemistry as a scientific Cinderella gained more evidence in the last decades with the advent of concoctions such as high throughput assay, system biology or combinatorial chemistry. While this is true, it is quite wrong that research results from top analytical labs largely influence the product pipeline in the pharmaceutical industry and also play a key role when it comes to process optimization and failure analysis. Potency assays for still regulated pharmaceuticals like digitalis; diagnostic test kits for parameters such as blood glucose, cholesterol or vitamin D 3; the role of technically sophisticated instruments, it is not at all appropriate to view analytical chemistry as a mere ‘service discipline.
Y. Li, T. Kind, J. Folz, A. Vaniya et al., "Spectral entropy outperforms MS/MS dot product similarity for small-molecule compound identification," Nature Methods, 2021. yuanyue.li
Y. Zhang, P. Cai, and G. Cheng, "A brief review of phenolic compounds identified from plants: Their extraction, analysis, and biological activity," Natural Product, 2022. sagepub.com
E. Rosenberg and R. Krska, "Analytical chemistry in front of the curtain!," 2024. ncbi.nlm.nih.gov
B. Debus, H. Parastar, and P. Harrington, "Deep learning in analytical chemistry," in Analytical Chemistry, Elsevier, 2021. [HTML]
J. He, X. Wen, L. Wu, H. Chen, J. Hu, and X. Hou, "Dielectric barrier discharge plasma for nanomaterials: Fabrication, modification and analytical applications," Trends in Analytical Chemistry, Elsevier, 2022. ssrn.com
B. Ashok Kumar, "Method Development and Validation of Stability Indicating Rphplc Method for Simultaneous Estimation of Levofloxacin and Azithromycin in Pharmaceutical Tablet Dosage Form.," 2012. [PDF]
P. Carracedo-Reboredo, J. Liñares-Blanco, "A review on machine learning approaches and trends in drug discovery," Computational and …, Elsevier, 2021. sciencedirect.com
S. Alam, M. M. R. Sarker, T. N. Sultana, "Antidiabetic phytochemicals from medicinal plants: prospective candidates for new drug discovery and development," *Frontiers in*, 2022. frontiersin.org
E. E. Patton, L. I. Zon, and D. M. Langenau, "Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials," Nature Reviews Drug Discovery, 2021. nih.gov
C. Cheng, "Applications of Hyphenated Analytical Techniques in Pharmaceutical Industry," 2011. [PDF]
S. S. R. Parimi, "Exploring How Sap Helps in Managing Clinical Trials, Research Data, and Collaboration in The Pharmaceutical Industry," IEJRD-International Multidisciplinary Journal, 2022. researchgate.net
P. C. Tiwari, R. Pal, and M. J. Chaudhary, "Artificial intelligence revolutionizing drug development: Exploring opportunities and challenges," Drug Development, 2023. researchgate.net
C. Zhang, "Fundamentals of environmental sampling and analysis," 2024. sut.ac.th
E. Noviana, T. Ozer, C. S. Carrell, and J. S. Link, "Microfluidic paper-based analytical devices: from design to applications," Chemical, 2021. [HTML]
Z. Meng and K. A. Mirica, "Covalent organic frameworks as multifunctional materials for chemical detection," Chemical Society Reviews, 2021. rsc.org
I. Siddique, "High-performance liquid chromatography: comprehensive techniques and cutting-edge innovations," European Journal of Advances in Engineering and …, 2023. ssrn.com
J.C. Alarcon-Barrera, S. Kostidis, and A. Ondo-Mendez, "Recent advances in metabolomics analysis for early drug development," *Drug Discovery Today*, 2022. sciencedirect.com
U. K. A. M. A. K. A. MODEBRLU and B. E. N. Y. BABY, "Analytical Techniques in Pharmaceutical Analysis for Samples Separation, Characterization, Determination and its Handling," 2019. [PDF]
M. E. I. Badawy, M. A. M. El-Nouby, P. K. Kimani, and L. W. Lim, "A review of the modern principles and applications of solid-phase extraction techniques in chromatographic analysis," Analytical, 2022. springer.com
T. Liangsupree, E. Multia, and M. L. Riekkola, "Modern isolation and separation techniques for extracellular vesicles," Journal of Chromatography A, 2021. sciencedirect.com
A. B. Kanu, "Recent developments in sample preparation techniques combined with high-performance liquid chromatography: A critical review," Journal of Chromatography A, 2021. sciencedirect.com
S. C. Moldoveanu and V. David, "Modern sample preparation for chromatography," 2021. [HTML]
A. Biancolillo and F. Marini, "Chemometric Methods for Spectroscopy-Based Pharmaceutical Analysis," 2018. ncbi.nlm.nih.gov
H. Parastar and R. Tauler, "Big (bio) chemical data mining using chemometric methods: a need for chemists," Angewandte Chemie, 2022. csic.es
P. H. Stefanuto, A. Smolinska, and J. F. Focant, "Advanced chemometric and data handling tools for GCŨGC-TOF-MS: Application of chemometrics and related advanced data handling in chemical separations," TrAC Trends in Analytical, Elsevier, 2021. [HTML]
M. Kharbach, M. Alaoui Mansouri, M. Taabouz, and H. Yu, "Current application of advancing spectroscopy techniques in food analysis: data handling with chemometric approaches," Foods, 2023. mdpi.com
Z. J. Baum, X. Yu, P. Y. Ayala, and Y. Zhao, "Artificial intelligence in chemistry: current trends and future directions," *Journal of Chemical*, 2021. acs.org
L. Jiang, M. M. Hassan, S. Ali, H. Li, and R. Sheng, "Evolving trends in SERS-based techniques for food quality and safety: A review," Trends in Food Science & Technology, 2021. [HTML]
C. Wang, M. Liu, Z. Wang, S. Li et al., "Point-of-care diagnostics for infectious diseases: From methods to devices," Nano Today, 2021. nih.gov
S. Liu, J. M. Yu, Y. C. Gan, X. Z. Qiu, Z. C. Gao, and H. Wang, "Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications," Military Medical, 2023. springer.com
D. C. de Andrade, S. A. Monteiro, and J. Merib, "A review on recent applications of deep eutectic solvents in microextraction techniques for the analysis of biological matrices," Advances in Sample Preparation, 2022. sciencedirect.com
A. Blanco-Gonzalez, A. Cabezon, A. Seco-Gonzalez, and others, "The role of AI in drug discovery: challenges, opportunities, and strategies," Pharmaceuticals, 2023. mdpi.com
C. S. Adamson, K. Chibale, R. J. M. Goss, "Antiviral drug discovery: preparing for the next pandemic," Chemical Society, 2021. rsc.org
A. V. Sadybekov and V. Katritch, "Computational approaches streamlining drug discovery," Nature, 2023. nature.com
R. Naresh, "Method Development and Validation for the Estimation of Tenofovir by Reverse Phase Liquid Chromatography.," 2011. [PDF]
F. Meissner, J. Geddes-McAlister, and M. Mann, "The emerging role of mass spectrometry-based proteomics in drug discovery," Nature Reviews Drug, 2022. [HTML]
E. Defossez, J. Bourquin, and S. von Reuss, "Eight key rules for successful data‐dependent acquisition in mass spectrometry‐based metabolomics," Mass Spectrometry, 2023. wiley.com
M. Betz, K. Saxena, and H. Schwalbe, "Biomolecular NMR: a chaperone to drug discovery," 2006. ncbi.nlm.nih.gov
M. Zloh, "NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties," 2019. ncbi.nlm.nih.gov
K. Y Kavitha, "Development and Validation of Liquid Chromatographic Methods for the Estimation of Selected Drugs in Multi-Components Dosage Forms," 2013. [PDF]
R. Deidda, T. Hermane Avohou, H. Jambo, A. Dispas et al., "Principles of Analytical Quality by Design for the development of quality control methods in a pharmaceutical context," 2019. [PDF]
V. Starokozhko, M. Kallio, Å. K. Howell, and A. M. Salmi, "Strengthening regulatory science in academia: STARS, an EU initiative to bridge the translational gap," Drug Discovery Today, 2021. sciencedirect.com
A. Najmi, S. A. Javed, M. Al Bratty, and H. A. Alhazmi, "Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents," Molecules, 2022. mdpi.com
V. T. Sabe, T. Ntombela, L. A. Jhamba, "Current trends in computer aided drug design and a highlight of drugs discovered via computational techniques: A review," Journal of Medicinal, 2021. [HTML]
M. Schlander, K. Hernandez-Villafuerte, C. Y. Cheng, "How much does it cost to research and develop a new drug? A systematic review and assessment," Springer, 2021. springer.com
B. Nigović and M. Sertić, "Onečišćenja u lijekovima," 2012. [PDF]
C. Sarkar, B. Das, V. S. Rawat, and J. B. Wahlang, "Artificial intelligence and machine learning technology driven modern drug discovery and development," International Journal of ..., 2023. mdpi.com
S. Vatansever, A. Schlessinger, and D. Wacker, "Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions," Medicinal Research, 2021. wiley.com
A. Nayarisseri, R. Khandelwal, and P. Tanwar, "Artificial intelligence, big data and machine learning approaches in precision medicine & drug discovery," Current Drug, 2021. researchgate.net
E. Obłąk, B. Futoma-Kołoch, and A. Wieczyńska, "Biological activity of quaternary ammonium salts and resistance of microorganisms to these compounds," *World Journal of Microbiology*, 2021. [HTML]
P. Bakun, B. Czarczynska-Goslinska, and T. Goslinski, "In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine," Medicinal Chemistry, 2021. springer.com
Y. L. Chew, M. A. Khor, and Y. Y. Lim, "Choices of chromatographic methods as stability indicating assays for pharmaceutical products: A review," 2021. ncbi.nlm.nih.gov
K. Vaso, M.S.I. Pasho, and E. Marku, "Analytical Assessment of Nitroimidazoles in Honey Samples from South eastern Albania, utilizing SupelMIP™ SPE Columns with LC-MS/MS," in 10th World Congress on ..., 2024. avestia.com
M. R. Shen, Y. He, and S. M. Shi, "Development of chromatographic technologies for the quality control of Traditional Chinese Medicine in the Chinese Pharmacopoeia," Journal of Pharmaceutical Analysis, 2021. sciencedirect.com
M. Haji, L. Kerbache, and T. Al-Ansari, "Food quality, drug safety, and increasing public health measures in supply chain management," Processes, 2022. mdpi.com
C. M. White, T. Browne, "Inherent dangers of using non–US Food and Drug Administration–approved substances of abuse," The Journal of Clinical, 2021. wiley.com
A. Thakur, Z. Tan, T. Kameyama, "Bioanalytical strategies in drug discovery and development," Drug Metabolism, 2021. [HTML]
S. R. Nikam, A. S. Jagdale, and S. S. Boraste, "Bioanalysis-method development, validation, sample preparation, its detection techniques and its application," 2021. [HTML]
Álvaro Fernández-Ochoa, M. de la Luz Cádiz-Gurrea, P. Fernández-Moreno, A. Rojas-García et al., "Recent Analytical Approaches for the Study of Bioavailability and Metabolism of Bioactive Phenolic Compounds," 2022. ncbi.nlm.nih.gov
G. Tiwari and R. Tiwari, "Bioanalytical method validation: An updated review," 2010. ncbi.nlm.nih.gov
K. Trzeciak, A. Chotera-Ouda, and I. I. Bak-Sypien, "Mesoporous silica particles as drug delivery systems—the state of the art in loading methods and the recent progress in analytical techniques for monitoring these," Pharmaceutics, 2021. mdpi.com
M. I. Khan, M. I. Hossain, and M. K. Hossain, "Recent progress in nanostructured smart drug delivery systems for cancer therapy: a review," ACS Applied Bio, 2022. [HTML]
I. Grint, F. Crea, and R. Vasiliadou, "The Combination of Electrochemistry and Microfluidic Technology in Drug Metabolism Studies," 2022. ncbi.nlm.nih.gov
K. A. Krautkramer, J. Fan, and F. Bäckhed, "Gut microbial metabolites as multi-kingdom intermediates," Nature Reviews Microbiology, 2021. [HTML]
S. Dewanjee, P. Chakraborty, and H. Bhattacharya, "Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress," Free Radical Biology, Elsevier, 2022. google.com
T. Ge, X. Gu, R. Jia, S. Ge, and P. Chai, "Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities," Cancer, 2022. wiley.com
A. J. P. O. de Almeida, J. C. P. L. de Oliveira, "ROS: basic concepts, sources, cellular signaling, and its implications in aging pathways," Oxidative Medicine, 2022. wiley.com
S. Q. Pantaleão, P. O. Fernandes, and J. E. Gonçalves, "Recent advances in the prediction of pharmacokinetics properties in drug design studies: a review," Wiley Online Library, 2022. wiley.com
A. C. Dalgård Dunvald, D. Bork Iversen, A. Ludvig Ohm Svendsen, K. Agergaard et al., "Tutorial: Statistical analysis and reporting of clinical pharmacokinetic studies," 2022. ncbi.nlm.nih.gov
F. Pognan, M. Beilmann, H. Boonen, and A. Czich, "The evolving role of investigative toxicology in the pharmaceutical industry," … reviews drug discovery, 2023. nature.com
C. Ma, Y. Peng, H. Li, and W. Chen, "Organ-on-a-chip: a new paradigm for drug development," Trends in pharmacological sciences, 2021. nih.gov
M. Lee Whitmire, P. Bryan, T. R. Henry, J. Holbrook et al., "NonClinical Dose Formulation Analysis Method Validation and Sample Analysis," 2010. ncbi.nlm.nih.gov
S. S. Bharate, S. B. Bharate, and A. N. Bajaj, "Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients: a comprehensive review," 1970. [PDF]
A. C. Walker, "Comparative analysis of the dissolution performance of aspirin tablets in the usp apparatus 2 and in a minivessel dissolution system," 2017. [PDF]
N. Fotaki, D. D'arcy, J. Demuth, and A. Hermans, "In Vitro Product Performance Testing of Oral Drug Products: View of the USP Expert Panel," Dissolution, 2024. dissolutiontech.com
J. H. Seo and R. Mittal, "Computational modeling of drug dissolution in the human stomach," Frontiers in Physiology, 2022. frontiersin.org
A. A. Halwani, "Development of pharmaceutical nanomedicines: from the bench to the market," Pharmaceutics, 2022. mdpi.com
P. Liu, G. Chen, and J. Zhang, "A review of liposomes as a drug delivery system: current status of approved products, regulatory environments, and future perspectives," Molecules, 2022. mdpi.com
W. Wang, Z. Ye, H. Gao, and D. Ouyang, "Computational pharmaceutics-A new paradigm of drug delivery," Journal of Controlled Release, 2021. [HTML]
R. Kaur Dhamoon, H. Popli, G. Aggarwal, and M. Gupta, "Particle Size Characterization- Techniques, Factors and Quality-by-design Approach," 2018. [PDF]
L. Peltonen, "Practical guidelines for the characterization and quality control of pure drug nanoparticles and nano-cocrystals in the pharmaceutical industry," 2018. [PDF]
N. Lion, F. Reymond, H. H. Girault, and J. S. Rossier, "Why the move to microfluidics for protein analysis?," 2005. [PDF]
P. Zhao, J. Wang, C. Chen, J. Wang et al., "Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening," 2022. ncbi.nlm.nih.gov
H. Aldewachi, R. N. Al-Zidan, M. T. Conner, and M. M. Salman, "High-throughput screening platforms in the discovery of novel drugs for neurodegenerative diseases," Bioengineering, 2021. mdpi.com
R. P. Simon, T. T. Häbe, R. Ries, M. Winter, "Acoustic ejection mass spectrometry: a fully automatable technology for high-throughput screening in drug discovery," in *Journal of Drug Discovery*, 2021. sagepub.com
P. Szymański, M. Markowicz, and E. Mikiciuk-Olasik, "Adaptation of High-Throughput Screening in Drug Discovery—Toxicological Screening Tests," 2011. ncbi.nlm.nih.gov
L. Huber, "Validation of computerized analytical systems," 2023. [HTML]
P. A. Østergaard, H. Lund, and J. Z. Thellufsen, "Review and validation of EnergyPLAN," Renewable and Sustainable Energy, Elsevier, 2022. sciencedirect.com
C. E. Covarrubias, T. A. Rivera, C. A. Soto, T. Deeks et al., "Current GMP standards for the production of vaccines and antibodies: An overview," 2022. ncbi.nlm.nih.gov
